Pharmaceutical Applications of Hyperspectral Imaging

Hyperspectral imaging is ideal for analyzing solid form pharmaceutical products such as films, blends, and tablets either during on-line manufacturing or in laboratory formulation development. By collecting spatial and spectral (chemical) information simultaneously, one can rapidly image a sample or product line. Hyperspectral imaging provides information about the spatial distribution of chemical components within the sample. The homogeneity or patterned dispersion of chemical components is often critical in the end effect of the pharmaceutical product, and hyperspectral imaging provides precisely this information without contacting or destroying the sample or product, and without requiring a high heat load from illumination.

How it works: The hyperspectral camera collects both spatial and spectral (chemical) information by employing a push-broom imaging method. As opposed to a staring array, the camera images one line of the product at a time and as the sample tray or product moves underneath the camera (or as the camera is moved over the sample), the whole image is collected. A full spectrum of each point is saved, resulting in a "hypercube" of data that can be analyzed to identify chemically distinct components and their spatial distribution within the product. This process is relatively quick and because only one line of the sample is imaged at a time, a high prolonged heat load from the illumination is not necessary.

Middleton Research offers complete hyperspectral workstations for in-lab use (see SisuCHEMA and Via-Spec system product brochures below). In addition, we can work with you to develop a hyperspectral system that is optimized for your specific application. We provide individual system components and consulting to integrate a specific system complete with a camera, illumination source, and software to meet your needs.

Please see the brochures below or contact us for further information.

Application Notes

SisuCHEMA™ in Pharmaceutical Applications

Monitoring of Continuous Manufacturing

High Speed Hyperspectral Chemical Imaging (Technical Paper)

Product Sheets

SisuCHEMA™ Hyperspectral Imaging Systems

Via-Spec™ Hyperspectral Transmission System

Hyperspectral Thin Film Measurement System Product Sheet

High-Speed Prediction Engine